| | Cherokee County | SC | 45021 | | Gaffney, SC 23500 | Greenville-Spartanburg-Anderson,
SC 273 | Central | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=CherokeeCounty+SC |
| | Chester County | SC | 45023 | | Charlotte-Concord-Gastonia,
NC-SC 16740 | Charlotte-Concord, NC-SC 172 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=ChesterCounty+SC |
| | Chesterfield County | SC | 45025 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=ChesterfieldCounty+SC |
| | Clarendon County | SC | 45027 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=ClarendonCounty+SC |
| | Colleton County | SC | 45029 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=ColletonCounty+SC |
| | Darlington County | SC | 45031 | | Florence, SC 22500 | | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=DarlingtonCounty+SC |
| | Dillon County | SC | 45033 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=DillonCounty+SC |
| | Dorchester County | SC | 45035 | | Charleston-North
Charleston, SC 16700 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=DorchesterCounty+SC |
| | Edgefield County | SC | 45037 | | Augusta-Richmond County,
GA-SC 12260 | | Outlying | metro county (urban) | federal/state
government-dependent | https://maps.google.com/?q=EdgefieldCounty+SC |
| | Fairfield County | SC | 45039 | | Columbia, SC 17900 | Columbia-Sumter-Orangeburg,
SC 192 | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=FairfieldCounty+SC |