| | Abbeville County | SC | 45001 | | Greenwood, SC 24940 | Greenville-Spartanburg-Anderson,
SC 273 | Outlying | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=AbbevilleCounty+SC |
| | Aiken County | SC | 45003 | | Augusta-Richmond County,
GA-SC 12260 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=AikenCounty+SC |
| | Allendale County | SC | 45005 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=AllendaleCounty+SC |
| | Anderson County | SC | 45007 | | Greenville-Anderson-Greer,
SC 24860 | Greenville-Spartanburg-Anderson,
SC 273 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=AndersonCounty+SC |
| | Bamberg County | SC | 45009 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=BambergCounty+SC |
| | Barnwell County | SC | 45011 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=BarnwellCounty+SC |
| | Beaufort County | SC | 45013 | | Hilton Head
Island-Bluffton-Port
Royal, SC 25940 | | Central | metro county (urban) | recreation | https://maps.google.com/?q=BeaufortCounty+SC |
| | Berkeley County | SC | 45015 | | Charleston-North
Charleston, SC 16700 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=BerkeleyCounty+SC |
| | Calhoun County | SC | 45017 | | Columbia, SC 17900 | Columbia-Sumter-Orangeburg,
SC 192 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=CalhounCounty+SC |
| | Charleston County | SC | 45019 | | Charleston-North
Charleston, SC 16700 | | Central | metro county (urban) | federal/state
government-dependent | https://maps.google.com/?q=CharlestonCounty+SC |