| | Darlington County | SC | 45031 | | Florence, SC 22500 | | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=DarlingtonCounty+SC |
| | Dillon County | SC | 45033 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=DillonCounty+SC |
| | Dorchester County | SC | 45035 | | Charleston-North
Charleston, SC 16700 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=DorchesterCounty+SC |
| | Edgefield County | SC | 45037 | | Augusta-Richmond County,
GA-SC 12260 | | Outlying | metro county (urban) | federal/state
government-dependent | https://maps.google.com/?q=EdgefieldCounty+SC |
| | Florence County | SC | 45041 | | Florence, SC 22500 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=FlorenceCounty+SC |
| | Hampton County | SC | 45049 | | | | | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=HamptonCounty+SC |
| | Jasper County | SC | 45053 | | Hilton Head
Island-Bluffton-Port
Royal, SC 25940 | | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=JasperCounty+SC |
| | Lee County | SC | 45061 | | | | | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=LeeCounty+SC |
| | McCormick County | SC | 45065 | | | | | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=McCormickCounty+SC |
| | Marion County | SC | 45067 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=MarionCounty+SC |