| | | Darlington County | SC | 45031 | | Florence, SC 22500 | | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=DarlingtonCounty+SC |
| | | Colleton County | SC | 45029 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=ColletonCounty+SC |
| | | Clarendon County | SC | 45027 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=ClarendonCounty+SC |
| | | Chesterfield County | SC | 45025 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=ChesterfieldCounty+SC |
| | | Chester County | SC | 45023 | | Charlotte-Concord-Gastonia,
NC-SC 16740 | Charlotte-Concord, NC-SC 172 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=ChesterCounty+SC |
| | | Cherokee County | SC | 45021 | | Gaffney, SC 23500 | Greenville-Spartanburg-Anderson,
SC 273 | Central | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=CherokeeCounty+SC |
| | | Charleston County | SC | 45019 | | Charleston-North
Charleston, SC 16700 | | Central | metro county (urban) | federal/state
government-dependent | https://maps.google.com/?q=CharlestonCounty+SC |
| | | Calhoun County | SC | 45017 | | Columbia, SC 17900 | Columbia-Sumter-Orangeburg,
SC 192 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=CalhounCounty+SC |
| | | Berkeley County | SC | 45015 | | Charleston-North
Charleston, SC 16700 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=BerkeleyCounty+SC |
| | | Beaufort County | SC | 45013 | | Hilton Head
Island-Bluffton-Port
Royal, SC 25940 | | Central | metro county (urban) | recreation | https://maps.google.com/?q=BeaufortCounty+SC |
