| | Yankton County | SD | 46135 | | Yankton, SD 49460 | | Central | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=YanktonCounty+SD |
| | Codington County | SD | 46029 | | Watertown, SD 47980 | | Central | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=CodingtonCounty+SD |
| | Clay County | SD | 46027 | | Vermillion, SD 46820 | | Central | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=ClayCounty+SouthDakota |
| | Lawrence County | SD | 46081 | | Spearfish, SD 43940 | Rapid City-Spearfish, SD 452 | Central | nonmetro county (rural) | recreation | https://maps.google.com/?q=LawrenceCounty+SD |
| | Lincoln County | SD | 46083 | | Sioux Falls, SD-MN 43620 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=LincolnCounty+SD |
| | McCook County | SD | 46087 | | Sioux Falls, SD-MN 43620 | | Outlying | metro county (urban) | farm-dependent | https://maps.google.com/?q=McCookCounty+SD |
| | Minnehaha County | SD | 46099 | | Sioux Falls, SD-MN 43620 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=MinnehahaCounty+SD |
| | Turner County | SD | 46125 | | Sioux Falls, SD-MN 43620 | | Outlying | metro county (urban) | farm-dependent | https://maps.google.com/?q=TurnerCounty+SD |
| | Union County | SD | 46127 | | Sioux City, IA-NE-SD 43580 | Sioux City-Le Mars,
IA-NE-SD 512 | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=UnionCounty+SD |
| | Custer County | SD | 46033 | | Rapid City, SD 39660 | Rapid City-Spearfish, SD 452 | Outlying | metro county (urban) | federal/state
government-dependent | https://maps.google.com/?q=CusterCounty+SD |