| | Newberry County | SC | 45071 | | Newberry, SC 35140 | Columbia-Sumter-Orangeburg,
SC 192 | Central | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=NewberryCounty+SC |
| | Orangeburg County | SC | 45075 | | Orangeburg, SC 36700 | Columbia-Sumter-Orangeburg,
SC 192 | Central | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=OrangeburgCounty+SC |
| | Oconee County | SC | 45073 | | Seneca, SC 42860 | Greenville-Spartanburg-Anderson,
SC 273 | Central | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=OconeeCounty+SC |
| | Spartanburg County | SC | 45083 | | Spartanburg, SC 43900 | Greenville-Spartanburg-Anderson,
SC 273 | Central | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=SpartanburgCounty+SC |
| | Union County | SC | 45087 | | Spartanburg, SC 43900 | Greenville-Spartanburg-Anderson,
SC 273 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=UnionCounty+SC |
| | Sumter County | SC | 45085 | | Sumter, SC 44940 | Columbia-Sumter-Orangeburg,
SC 192 | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=SumterCounty+SC |