| | Marion County | MO | 29127 | | Hannibal, MO 25300 | Quincy-Hannibal, IL-MO 448 | Central | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=MarionCounty+MO |
| | Mercer County | MO | 29129 | | | | | nonmetro county (rural) | farm-dependent | https://maps.google.com/?q=MercerCounty+MO |
| | Miller County | MO | 29131 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=MillerCounty+MO |
| | Mississippi County | MO | 29133 | | Sikeston, MO 43460 | Cape Girardeau-Sikeston,
MO-IL 164 | Outlying | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=MississippiCounty+MO |
| | Monroe County | MO | 29137 | | | | | nonmetro county (rural) | farm-dependent | https://maps.google.com/?q=MonroeCounty+MO |
| | Montgomery County | MO | 29139 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=MontgomeryCounty+MO |
| | Morgan County | MO | 29141 | | | | | nonmetro county (rural) | recreation | https://maps.google.com/?q=MorganCounty+MO |
| | New Madrid County | MO | 29143 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=NewMadridCounty+MO |
| | Nodaway County | MO | 29147 | | Maryville, MO 32340 | | Central | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=NodawayCounty+MO |
| | Oregon County | MO | 29149 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=OregonCounty+MO |