| | Carlisle County | KY | 21039 | | Paducah, KY-IL 37140 | Paducah-Mayfield, KY-IL 424 | Outlying | nonmetro county (rural) | farm-dependent | https://maps.google.com/?q=CarlisleCounty+KY |
| | Carter County | KY | 21043 | | Huntington-Ashland,
WV-KY-OH 26580 | Charleston-Huntington-Ashland,
WV-OH-KY 170 | Outlying | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=CarterCounty+KY |
| | Christian County | KY | 21047 | | Clarksville, TN-KY 17300 | | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=ChristianCounty+KY |
| | Clark County | KY | 21049 | | Lexington-Fayette, KY 30460 | Lexington-Fayette--Richmond--Frankfort,
KY 336 | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=ClarkCounty+KY |
| | Clay County | KY | 21051 | | Corbin, KY 18340 | Middlesborough-Corbin, KY 371 | Outlying | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=ClayCounty+KY |
| | Edmonson County | KY | 21061 | | Bowling Green, KY 14540 | Bowling
Green-Glasgow-Franklin,
KY 150 | Outlying | metro county (urban) | federal/state
government-dependent | https://maps.google.com/?q=EdmonsonCounty+KY |
| | Estill County | KY | 21065 | | Richmond-Berea, KY 40080 | Lexington-Fayette--Richmond--Frankfort,
KY 336 | Outlying | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=EstillCounty+KY |
| | Floyd County | KY | 21071 | | Pikeville, KY 38210 | | Outlying | nonmetro county (rural) | mining-dependent | https://maps.google.com/?q=FloydCounty+KY |
| | Gallatin County | KY | 21077 | | Cincinnati, OH-KY-IN 17140 | Cincinnati-Wilmington,
OH-KY-IN 178 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=GallatinCounty+KY |
| | Grant County | KY | 21081 | | Cincinnati, OH-KY-IN 17140 | Cincinnati-Wilmington,
OH-KY-IN 178 | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=GrantCounty+KY |