| | Ohio County | KY | 21183 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=OhioCounty+KY |
| | Owen County | KY | 21187 | | | | | nonmetro county (rural) | farm-dependent | https://maps.google.com/?q=OwenCounty+KY |
| | Owsley County | KY | 21189 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=OwsleyCounty+KY |
| | Perry County | KY | 21193 | | | | | nonmetro county (rural) | mining-dependent | https://maps.google.com/?q=PerryCounty+KY |
| | Pike County | KY | 21195 | | Pikeville, KY 38210 | | Central | nonmetro county (rural) | mining-dependent | https://maps.google.com/?q=PikeCounty+KY |
| | Powell County | KY | 21197 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=PowellCounty+KY |
| | Pulaski County | KY | 21199 | | Somerset, KY 43700 | | Central | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=PulaskiCounty+KY |
| | Robertson County | KY | 21201 | | | | | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=RobertsonCounty+KY |
| | Rockcastle County | KY | 21203 | | Richmond-Berea, KY 40080 | Lexington-Fayette--Richmond--Frankfort,
KY 336 | Outlying | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=RockcastleCounty+KY |
| | Rowan County | KY | 21205 | | | | | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=RowanCounty+KY |