| | Edgar County | IL | 17045 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=EdgarCounty+IL |
| | Edwards County | IL | 17047 | | | | | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=EdwardsCounty+IL |
| | Effingham County | IL | 17049 | | Effingham, IL 20820 | | Central | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=EffinghamCounty+IL |
| | Fayette County | IL | 17051 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=FayetteCounty+IL |
| | Franklin County | IL | 17055 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=FranklinCounty+IL |
| | Gallatin County | IL | 17059 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=GallatinCounty+IL |
| | Greene County | IL | 17061 | | | | | nonmetro county (rural) | farm-dependent | https://maps.google.com/?q=GreeneCounty+IL |
| | Hamilton County | IL | 17065 | | | | | nonmetro county (rural) | farm-dependent | https://maps.google.com/?q=HamiltonCounty+IL |
| | Hancock County | IL | 17067 | | | | | nonmetro county (rural) | nonspecialized | https://maps.google.com/?q=HancockCounty+IL |
| | Hardin County | IL | 17069 | | | | | nonmetro county (rural) | mining-dependent | https://maps.google.com/?q=HardinCounty+IL |