| | | Florence County | SC | 45041 | | Florence, SC 22500 | | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=FlorenceCounty+SC |
| | | Georgetown County | SC | 45043 | | Murrells Inlet, SC 34680 | Myrtle Beach-Conway,
SC-NC 396 | Central | nonmetro county (rural) | recreation | https://maps.google.com/?q=GeorgetownCounty+SouthCarolina |
| | | Greenville County | SC | 45045 | | Greenville-Anderson-Greer,
SC 24860 | Greenville-Spartanburg-Anderson,
SC 273 | Central | metro county (urban) | nonspecialized | https://maps.google.com/?q=GreenvilleCounty+SC |
| | | Greenwood County | SC | 45047 | | Greenwood, SC 24940 | Greenville-Spartanburg-Anderson,
SC 273 | Central | nonmetro county (rural) | manufacturing-dependent | https://maps.google.com/?q=GreenwoodCounty+SC |
| | | Hampton County | SC | 45049 | | | | | nonmetro county (rural) | federal/state
government-dependent | https://maps.google.com/?q=HamptonCounty+SC |
| | | Horry County | SC | 45051 | | Myrtle Beach-Conway-North
Myrtle Beach, SC-NC 34820 | Myrtle Beach-Conway,
SC-NC 396 | Central | metro county (urban) | recreation | https://maps.google.com/?q=HorryCounty+SC |
| | | Jasper County | SC | 45053 | | Hilton Head
Island-Bluffton-Port
Royal, SC 25940 | | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=JasperCounty+SC |
| | | Kershaw County | SC | 45055 | | Columbia, SC 17900 | Columbia-Sumter-Orangeburg,
SC 192 | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=KershawCounty+SC |
| | | Lancaster County | SC | 45057 | | Charlotte-Concord-Gastonia,
NC-SC 16740 | Charlotte-Concord, NC-SC 172 | Outlying | metro county (urban) | nonspecialized | https://maps.google.com/?q=LancasterCounty+SC |
| | | Laurens County | SC | 45059 | | Greenville-Anderson-Greer,
SC 24860 | Greenville-Spartanburg-Anderson,
SC 273 | Outlying | metro county (urban) | manufacturing-dependent | https://maps.google.com/?q=LaurensCounty+SC |
